Edgar Kooijman
Associate Professor
Biography
The Kooijman lab is broadly interested in the physical chemistry of membrane lipids, and protein-lipid interactions. Our work is divided into two main directions: 1) elucidating the ionization properties of glycerophosphilipids, and lipid spontaneous curvature and how these influence how proteins interact with individual lipids and membranes, and 2) how proteins interact with intracellular lipid droplets, specifically we focus on the perilipin protein family.
Keywords: Biophysics protein/lipid interactions, physical chemistry of lipid structure and function, model membranes, neutral lipid storage (lipid droplets/adipocytes).
Education
2006 Ph.D., Utrecht University, The Netherlands (Biochemistry of Membranes)
2001 MS., Kent State University (Physics)
1998 Engineering degree, Rijswijk Institute of Technology, The Netherlands (Applied Physics Engineering)
1997 Diploma process technology, Dudok College, Hilversum, The Netherlands
2001 MS., Kent State University (Physics)
1998 Engineering degree, Rijswijk Institute of Technology, The Netherlands (Applied Physics Engineering)
1997 Diploma process technology, Dudok College, Hilversum, The Netherlands
Publications
- Desmond Owusu Kwarteng, Mahinda Gangoda, and Edgar E. Kooijman, The effect of methylated phosphatidylethanolamine derivatives on the ionization properties of signaling phosphatidic acid, Biophysical Chemistry, 296: 107005 (2023) DOI:10.1016/j.bpc.2023.10
- Kelum Perera, Thiloka M Dassanayake, Mahesha Jeewanthi, Nilanthi P Haputhanthrige, Songping D Huang, Edgar Kooijman, Elizabeth Mann, and Antal Jákli, Liquid crystal-based detection of antigens with ELISA sensitivity, Advanced Materials Interfaces, 9(25):
- Zachery T. Graber, Desmond Owusu Kwarteng, Shannon Rapovy, Yannis Koukanas, Hady Khalifa, Jean Mutambuze, and Edgar E. Kooijman, The electrostatic basis of diacylglycerol pyrophosphate – protein interaction, Cells 11(2): 290 (2022) DOI: 10.3390/cells11020
- Amber R Titus and Edgar E Kooijman, Chapter Two - Current methods for studying intracellular liquid-liquid phase separation, Editor(s): Michael A. Model, Irena Levitan, Current Topics in Membranes, Academic Press, Volume 88: 55-73 (2021) DOI: 10.1016/bs.c
- Desmond Owusu Kwarteng, Priya Putta, Edgar E. Kooijman, Ionization properties of monophosphoinositides in mixed model membranes, BBA-Biomem, 1863(11): 183692 (2021) DOI: 10.1016/j.bbamem.2021.18369
- Mona Mirheydari, Priya Putta, Elizabeth K Mann, Edgar E Kooijman, Interaction of Two Amphipathic α-Helix Bundle Proteins, ApoLp-III and ApoE 3, with the Oil–Aqueous Interface, J Phys Chem B, 125(18): 4746-4756 (2021) DOI: 10.1021/acs.jpcb.1c00271
- Amber R Titus, Ellyse N Ridgway, Rebecca Douglas, Elena Sánchez Brenes, Elizabeth K Mann, Edgar E Kooijman, The C-Terminus of Perilipin 3 Shows Distinct Lipid Binding at Phospholipid-Oil-Aqueous Interfaces, Membranes, 11(4): 265 (2021) DOI: 10.3390/membra
- Priya Putta, Emily Creque, Helen Piontkivska, Edgar E. Kooijman, Lipid-Protein Interactions for ECA1 an N-ANTH Domain Protein Involved in Stress Signaling in Plants, Chemistry and Physics of Lipids (2020) DOI: 10.1016/j.chemphyslip.2020.104919
- Amber R. Titus, Luisa A. Ferreira, Alexander I. Belgovsky, Edgar E. Kooijman, Elizabeth K. Mann, J. Adin Mann Jr., et al., Interfacial tension and mechanism of liquid-liquid phase separation in aqueous media, Phys Chem Chem Phys, 22:4574-4580 (2020)