My research laboratory primarily focuses on drug design and discovery studies targeting beta-lactam drug resistance (DR) systems and drug neurodegenerative disorders. Additionally, we emphasize research on disease mechanisms. The ultimate goal is identifying unprecedented drug targets and pathogenic pathways, developing effective therapeutic strategies, and designing new lead compounds to overcome drug resistance and neurodegenerative disorders.
We investigate the hypothalamic neuronal circuits that control that activity of gonadotropin-releasing homrone neurons, gonadotropin hormone secretion, gonadal function and fertility. Our research has focused in the past few years on how the central circadian clock influences the neuroendcorine control of ovulation in females.
We investigate water and ion balance, macromolecular crowding, cell stress and death, and new microscopic techniques.
We investigate genetic basis of organismal response to novel environments. Such response generally occurs through genetic adaptation, phenotypic plasticity or combination of these two processes. We are particularly interested in exploring the relative roles of genetic adaptation and phenotypic plasticity that underly a trait evolution. We integrate a variety of interdisciplinary approaches, including comparative ‘omics’ (Genomics, Transcriptomics, Epigenomics, Metagenomics and Metabolomics) and Eco-physiology to uncover the molecular basis underlying the processes of adaptive evolution.
We investigate the cellular and molecular mechanisms underlying the construction of the brain and functional neural circuitry, particularly genesis, positioning and connectivity of neurons in the brain. These processes are essential for communication across the brain and for generating cognitive, social and emotional behaviors.
