My research program is concerned with the neural mechanisms of learning and memory that underlie drug use and emotional regulation, with emphasis on neurophysiology. Compulsive drug seeking and drug taking are the hallmarks of addiction, and overcoming these behaviors has proven difficult. Regulating these behaviors can be achieved by enhancing extinction learning and inhibiting retrieval of drug-associated memories. Recent work in the lab has shown that drug seeking can be reduced or eliminated using a variety of pharmacological manipulations, and the neural mechanisms are currently under study. We use animal models of drug administration combined with electrophysiological (in vivo and in vitro), pharmacological, and molecular techniques. Currently, we are examining how sex differences and gonadal hormones contribute to extinction learning and retrieval. Understanding the neural bases of extinction and drug-associated memory retrieval could lead to the development of pharmacotherapies that improve therapeutic outcome of rehabilitation programs.